KRAS数据信号的刺激启动有的是个多步凑的操作过程，可以十分的KRAS翻意后绘制，人体细胞质导航定位与现象蛋白酶的互相用。The activation of KRAS signaling is a multi-step process that requires proper KRAS post-translation，plasma membrane-localization and interaction with effector proteins.在癌细胞外激刺功用下，从灭活的RAS-GDP到提高的RAS-GDP的被转化进十步推进了好几种数字信号通道的提高，表中包括MAPK通道、PI3k 通道和Ral-GEFs通道，表中以MAPK通道的优点作为显然。In response to extracellular stimuli, the conversion from inactive RAS-GDP to active RAS-GDP further promotes the activation of various signaling pathways, which includes MAPK pathway，PI3k pathway and the Ral-GEFs pathway,among them the MAPK pathway is the best characterized.RAS-GDP简单与RAF蛋白质综合，将RAF激酶一家从神经元质征集到膜上，在神经元膜上二聚化并活性。缴活的RAF之后对其中下游底物，即MEK and ERk通过一类别磷硝化作用反馈，并传导电流种子发芽数据信息。RAS-GDP directly binds to RAF protein,recruiting RAF Kinese family from cytoplasm to membranes，where they dimerize and become active. The activated RAF subsequently carries out a chain of phospholation reactions to its downstream substrates, MEK and ERk, and propagates the growth signal.
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