欧宝体育app 请解决为您分析GLP-1 目的体制。

GLP-1相结合GLP-1R(1)后，GLP-1R在胰岛β神经上皮细胞中偶联Gas核核蛋白，成功激活卡腺苷环化酶（AC），促成cAMP在神经上皮细胞内含锌量增大，可成功激活卡核核蛋白激酶A(PKA)和cAMP改善的鸟嘌呤核苷酸互相交换指数公式2（Epac-2）。After activation by full agonists such as GLP-1,GLP-1R(1)  couples with Gas activates adenolate cyclase(AC),and causes the accumulation of cAMP.With increasing cAMP levels, protein kinase A（PKA） and the exchange protein directly activated by cAMP-2(Epac-2) are also activated.PKA 和 Epac-2 需要关ATP忽略关系于的钾阴阳化合物节点，使神经元膜去极化；还需要激活开通电流值忽略关系于的钙阴阳化合物节点（VDCC）使钙阴阳化合物内流并形成瑜伽动作电势差，等等方式结果英文都将刺激性血糖忽略关系于性胰岛素的分泌出。PKA and Epac-2  trigger the closure of KATP and KV channels,which depolarizes the cell membrane opens voltage-dependent Calcium channels(VDCC) and causes Calcium influx and the promotion of insulin secretion by the islet beta cells

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